What Canakinumab is used for:

Canakinumab is used for treatment of the following inflammatory diseases:

Periodic fever syndromes:

- Still’s disease including adult onset Still’s disease (AOSD) and systemic juvenile idiopathic arthritis (SJIA)

Do not use Canakinumab:

- if you are allergic to Canakinumab or any of the other ingredients of this medicine.

Warnings and precautions:

Talk to your doctor or pharmacist before using Canakinumab:

- if you currently have an infection or if you have had repeated infections or a condition such as a known low level of white blood cells which makes you more likely to get infections.

- if you have or have ever had tuberculosis or direct contact with a person with an active tuberculosis infection.

- if you have signs of a liver disorder such as yellow skin and eyes, nausea, loss of appetite, dark-coloured urine and light-coloured stools.

Possible side effects :

- These include infections of any kind, upper abdominal pain, pain in joints (arthralgia), drop in level of white blood cells (leukopenia), abnormal kidney function test results (creatinine renal clearance decreased, proteinuria), injection site reaction (such as redness, swelling, warmth and itching), candida, feeling dizzy, spinning sensation (dizziness or vertigo), pain in the back or muscles, feeling weak or very tired (fatigue, asthenia), drop in level of white your blood (lipid metabolism disorder), abnormal liver function test results, heartburn (gastro-oesophageal reflux disease), drop in level of blood cells which help prevent bleeding (platelets).

Other medicines and Canakinumab:

Tell your doctor if you are taking any of the following medicines:

Live vaccines:

- You are advised to avoid being vaccinated with a type of vaccine called a live vaccine while you are being treated with Canakinumab.

- Your doctor may want to check your vaccination history and give you any vaccinations that you have missed before you start treatment with Canakinumab.

- Medicines called tumour necrosis factor (TNF) inhibitors, such as etanercept, adalimumab or infliximab.

How to use Canakinumab:

Canakinumab is intended for subcutaneous use.

Still’s disease (SJIA and AOSD):

- The recommended dose of Canakinumab for patients with Still’s disease with body weight of 7.5 kg and above is 4 mg/kg (up to a maximum of 300 mg). Canakinumab is injected every 4 weeks as a single dose.

Gouty arthritis:

- Your doctor will discuss with you the need to start or adjust a urate lowering therapy to lower the uric acid level in your blood.

- The recommended dose of Canakinumab for adult gouty arthritis patients is 150 mg given as a single dose at the time of a gouty arthritis attack.

How to store Canakinumab:

- Do not use this medicine after the expiry date which is stated on the label and carton.

- The solution should be used immediately after first piercing the vial stopper to prepare the injection.

- Do not use this medicine if you notice that the solution is not clear to opalescent.

Immunity Treatments

Certican tablet 0.25mg 60 Pcs